Beneficial Autoimmunity to Proinflammatory Mediators Restrains the Consequences of Self-Destructive Immunity
نویسندگان
چکیده
منابع مشابه
Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity.
Therapies that neutralize the function of TNF-alpha suppress rheumatoid arthritis (RA) but not osteoarthritis (OA). We show that patients suffering from RA but not OA have significant levels of autoantibodies directed to TNF-alpha. Thus, the immune system can selectively generate autoimmunity to proinflammatory mediators when such a response is beneficial for the host. A well-defined model of R...
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ژورنال
عنوان ژورنال: Immunity
سال: 2003
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(03)00291-7